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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NLK
All Species:
43.94
Human Site:
Y306
Identified Species:
69.05
UniProt:
Q9UBE8
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UBE8
NP_057315
527
58283
Y306
Q
E
V
V
T
Q
Y
Y
R
A
P
E
I
L
M
Chimpanzee
Pan troglodytes
XP_001147662
515
57030
Y294
Q
E
V
V
T
Q
Y
Y
R
A
P
E
I
L
M
Rhesus Macaque
Macaca mulatta
XP_001105594
573
63821
Y294
Q
E
V
V
T
Q
Y
Y
R
A
P
E
I
L
M
Dog
Lupus familis
XP_854001
515
57044
Y294
Q
E
V
V
T
Q
Y
Y
R
A
P
E
I
L
M
Cat
Felis silvestris
Mouse
Mus musculus
O54949
527
58294
Y306
Q
E
V
V
T
Q
Y
Y
R
A
P
E
I
L
M
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506943
489
54907
Y268
Q
E
V
V
T
Q
Y
Y
R
A
P
E
I
L
M
Chicken
Gallus gallus
XP_415915
515
57031
Y294
Q
E
V
V
T
Q
Y
Y
R
A
P
E
I
L
M
Frog
Xenopus laevis
Q8QGV6
447
50120
Y240
I
L
M
G
S
R
H
Y
R
S
A
I
D
I
W
Zebra Danio
Brachydanio rerio
XP_691913
533
58862
Y312
Q
E
V
V
T
Q
Y
Y
R
A
P
E
I
L
M
Tiger Blowfish
Takifugu rubipres
NP_001027920
443
50497
G244
S
I
D
I
W
S
V
G
C
I
F
A
E
L
L
Fruit Fly
Dros. melanogaster
NP_729316
430
48177
I232
D
V
W
S
V
G
C
I
F
G
E
L
L
G
R
Honey Bee
Apis mellifera
XP_394432
462
51375
Y240
Q
E
V
V
T
Q
Y
Y
R
A
P
E
I
L
M
Nematode Worm
Caenorhab. elegans
Q9U9Y8
634
71758
Y408
H
E
V
V
T
Q
Y
Y
R
A
P
E
L
L
M
Sea Urchin
Strong. purpuratus
XP_780259
503
56057
S271
T
D
L
L
G
T
P
S
M
E
D
M
K
Y
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39027
368
42280
C170
N
L
L
V
N
A
N
C
D
L
K
I
C
D
F
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.7
89
97.5
N.A.
99.8
N.A.
N.A.
76.6
96.5
66
94.5
79.5
64.3
63.3
46.5
61.1
Protein Similarity:
100
97.7
89.6
97.7
N.A.
99.8
N.A.
N.A.
78.7
96.7
73.8
95.8
81.9
73.8
73
57.7
71.9
P-Site Identity:
100
100
100
100
N.A.
100
N.A.
N.A.
100
100
13.3
100
6.6
0
100
86.6
0
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
100
100
53.3
100
20
6.6
100
93.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
0
0
0
67
7
7
0
0
7
% A
% Cys:
0
0
0
0
0
0
7
7
7
0
0
0
7
0
0
% C
% Asp:
7
7
7
0
0
0
0
0
7
0
7
0
7
7
0
% D
% Glu:
0
67
0
0
0
0
0
0
0
7
7
67
7
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
7
0
7
0
0
0
7
% F
% Gly:
0
0
0
7
7
7
0
7
0
7
0
0
0
7
0
% G
% His:
7
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% H
% Ile:
7
7
0
7
0
0
0
7
0
7
0
14
60
7
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
7
0
7
0
0
% K
% Leu:
0
14
14
7
0
0
0
0
0
7
0
7
14
74
7
% L
% Met:
0
0
7
0
0
0
0
0
7
0
0
7
0
0
67
% M
% Asn:
7
0
0
0
7
0
7
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
7
0
0
0
67
0
0
0
0
% P
% Gln:
60
0
0
0
0
67
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
7
0
0
74
0
0
0
0
0
7
% R
% Ser:
7
0
0
7
7
7
0
7
0
7
0
0
0
0
0
% S
% Thr:
7
0
0
0
67
7
0
0
0
0
0
0
0
0
0
% T
% Val:
0
7
67
74
7
0
7
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
7
0
7
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
0
0
0
0
0
0
67
74
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _